Communicable (CD) and non-communicable (NCD) diseases are current public health problems in sub-Saharan Africa, including Gabon where cardiovascular disease, diabetes and the carriage of intestinal parasites are prevalent in urban and rural areas. The Parcam project will assess the impact of these diseases, one on the other, in particular on their own occurrence thanks to the analysis of cardiovascular and metabolic risk factors (CMDRF) according to the parasitism.
Faculté de Médecine, Université des Sciences de la Santé (DPM-USS-LIBREVILLE) GABON.
Professor Marielle Karine BOUYOU-AKOTET
Reference : TMA2017GSF-1956
To be recruited
Inflammatory response and dysbiosis due to IPIs lead to dyslipidemia, type 2 diabetes and their cardiovascular (CVD) consequences. This will be translated into higher frequency of these CMD risk factors (CMDRF) in participants chronically or repeatedly infected when compared to uninfected participants. As exposition to IPI and type of parasitism are different between urban and rural areas, biomarkers of CMDRF will show different patterns according to the urbanisation. Precisely, we hypothesise that there will be more metabolic syndrome, more inflammation (as measured by IL-6, TNF-α, hsCRP) and more monocyte activation (as measured by sCD14) in chronically or repeatedly parasite-infected than in uninfected participants with difference according to urbanisation.
Non communicable diseases (NCDs) and Infectious diseases (IDs), such as malaria and intestinal parasites are highly prevalent in sub-Saharan Africa interact each other
experienced and young researchers has well as clinicians of the Université des Sciences de la Santé, assisted by local and international experts.
The project is divided into four (4) work packages that are closely related, it includes WP1 which is the project management, WP2 the implementation and development of the study, WP3 Capacity building, WP4: Information…
The study is performed through three phases
Phase I : Site preparation
The population and the chief from the districts of Libreville and Koulamoutou from two provinces in Gabon …
Phase II : Enrolment and cross-secionel survey
Will be the cross sectional survey, which corresponds to the screening for physical and biological risk factors over a 6 month-period …
Phase III : Propective cohort study
Will be the 18-month prospective cohort study comparing the frequency of the occurrence of CMDRF …